Postdoc (f/m/x) - Analyzing the effectiveness and safety of a novel RNA delivery platform
Postdoc (f/m/x) - Analyzing the effectiveness and safety of a novel RNA delivery platform
102856
Full time
39 hrs./week
Neuherberg near Munich
At Helmholtz Munich, we develop groundbreaking solutions for a healthier society in a rapidly changing world. We believe that diverse perspectives drive innovation. Through strong partnerships, we accelerate the transfer of new ideas from the lab to real-life applications, improving lives.
Recently, our Gene Editing group at the Institute of Stem Cell Research developedSynthetic Transfer Vehicles (STVs), a programmable protein-based RNA delivery platform that packages defined RNA cargos and delivers them to specific cell types. STVs consist of a synthetic protein that is assembled from natural and AI-designed protein domains, along with an engineered fusogenic protein. The technology has been recognized with them4 Award, the GO-Bio next program, and is currently under revision in a top-tier journal (preprint: 10.21203/rs.3.rs-5123765/v1).
We now aim to translate this platform by delivering gene editing tools, mRNA therapeutics, and other functional cargos into disease models. To drive this effort, we are seeking a highly motivated postdoctoral researcher (f/m/x) with a strong interest in advancing molecular technologies toward clinical application.
Your tasks
- Testing the efficacy of STV-delivered therapeutic cargos in animal models
- Characterizing immunological, cellular, and molecular responses to different cargo RNAs in animal models
- Writing manuscripts and drafting scientific illustrations
- Contributing to patent applications
- Supervising students (if desired)
Your profile
Your Scientific Qualifications
- PhD degree in Biology / Life Sciences / Biotechnology / Biochemistry or related fields
- Excellent publication record, preferably with at least one first-author publication
- Extensive experience with handling and analyzing animal models
- Valid qualifications and certifications for working with mice
- Hands-on experience in analytical techniques (e.g., biochemical assays, advanced Imaging technologies, Immunological and toxicological assays)
- Experience with genetically encoded delivery vehicles
Your Personal Qualifications
- Enthusiasm for applying molecular tools to solve biomedical needs
- Drive to work toward highly ambitious scientific goals, passion for innovating at the interface of research and clinical translation
- Willingness and ability to convert scientific work into high-impact publications and patents
- Commitment to working in a fast-moving and highly competitive field as well as in a dynamic and highly collaborative group
- Excellent written and spoken communication skills in English
If you fulfill all the requirements, you may be eligible for a salary grade of up to E 13. Social benefits are based on the Collective Wage Agreement for Public-Sector Employees (TVöD). This position is for a fixed term of 2,5 years.
Managing Director Mike Frieser:
„We believe that diversity is the key to groundbreaking research and innovative solutions. Our flexible working models and remote options create a supportive environment for balancing work and family life. For us, contributing to a healthier society in such an inspiring workplace is truly meaningful.“
Get to know us (https://www.helmholtz-munich.de/en/career)
Benefits
- Scientific ResourcesState-of-the-art infrastructure and Core Facilities
- International Staff ServiceSupport with the relocation and integration process in Germany
- Career DevelopmentPostdoc program, scientific training & career center with tailored offers
- Family SupportOn-site kindergarten, holiday care, care for the elderly
- Health PromotionSports, company doctor, mental health initiatives
- Recreation30 days annual leave, flexi days, plus public holidays
Interested in applying?
If you have any questions, feel free to contact Florian Giesert, florian.giesert@helmholtz-munich.de, who will be happy to help.